Dr. Karthick Vasudevan Associate Professor

Specialization

Bioinformatics

Areas Of Interest

Drug design, Advanced Genomics and computational biology

Qualification

M.Sc., Ph.D, Post doc

Teaching Experience

4.5

Awards & Recognition

• Year-2013 & 2014- Research Award, VIT university.

Vidwan ID/Profile URL

Scopus ID/Google Scholar ID

Funded Project (amount sanctioned)

• 12,41,804 INR (ICMR-Adhoc)

Publications In Refereed Journals

Key Publications (Only Q1 & Q2 Rated)

• Vasudevan K, Kumar DT, Kumar SU, Saleem A, Nagasundaram N, Siva R, Tayubi IA, Doss CG, Zayed H. A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease. Current Opinion in Pharmacology. 2021 Dec 1;61:28-35.
• Opintan JA, Will RC, Kuma GK, Osei M, Akumwena A, Boateng G, Owusu-Okyere G, Antwi L, Opare D, Pragasam AK, Vasudevan K. Phylogenetic and antimicrobial drug resistance analysis of Vibrio cholerae O1 isolates from Ghana. Microbial Genomics. 2021 Oct 29;7(10):000668.
• Will RC, Ramamurthy T, Sharma NC, Veeraraghavan B, Sangal L, Haldar P, Pragasam AK, Vasudevan K, Kumar D, Das B, Heinz E. Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae. Nature communications. 2021 Mar 8;12(1):1-8.
• Shankar C, Basu S, Lal B, Shanmugam S, Vasudevan K, Mathur P, Ramaiah S, Anbarasu A, Veeraraghavan B. Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence. Frontiers in Cellular and Infection Microbiology. 2021;11.
• Vasudevan K, Jacob JJ, Pragasam AK, Gunasekaran K, Kang G, Veeraraghavan B, Mutreja A. Evolutionary tracking of SARS-CoV-2 genetic variants highlights intricate balance of stabilizing and destabilizing mutations. Mbio
• Muthuirulandi Sethuvel, D. P., Mutreja, A., Pragasam, A. K., Vasudevan, K., Murugan, D., Anandan, S., ... & Veeraraghavan, B. (2020). Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant Shigella sonnei and Local Persistence of S. flexneri Clones in India. Msphere, 5(5), e00569-20.
• Shankar, C., Jacob, J. J., Vasudevan, K., Biswas, R., Manesh, A., Sethuvel, D. P. M., ... & Veeraraghavan, B. (2020). Emergence of multidrug resistant hypervirulent ST23 Klebsiella pneumoniae: multidrug resistant plasmid acquisition drives evolution. Frontiers in cellular and infection microbiology, 10, 719.

Other Publications

• Bakthavatchalam YD, Vasudevan K, Rao S, Varughese S, Rupali P, Gina M, Zervos M, Peter JV, Veeraraghavan B. Genomic portrait of community-associated methicillin-resistant Staphylococcus aureus ST772-SCCmec V lineage from India. Gene Reports. 2021 Jun 5:101235.
• Sharma NC, Anandan S, Ragupathi NK, Sethuvel DP, Vasudevan K, Kumar D, Gupta SK, Sangal L, Veeraraghavan B. Genetic diversity of clinical Bordetella pertussis ST2 strains in comparison with vaccine reference strains of India. Journal of Genomics. 2021;9:38.
• Shankar C, Basu S, Lal B, Shanmugam S, Vasudevan K, Mathur P, Ramaiah S, Anbarasu A, Veeraraghavan B. Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence. Frontiers in Cellular and Infection Microbiology. 2021;11.
• Yamuna Devi Bakthavatchalam, Karthick Vasudevan, Anushree Amladi, Shalini Anandan, John Victor Peter, Balaji Veeraraghavan (2021). Hybrid assembly of multi-drug resistant, highly virulent panIndia ST772-MRSA lineage: maximising its potential for dissemination similar to USA300 clone. Genomics
• Jobin J Jacob , Agila K Pragasam , Karthick Vasudevan , Balaji Veeraraghavan , Gagandeep Kang, Jacob John , Vasant Nagvekar , Ankur Mutreja. Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance (2021). Genomics
• Dhiviya Prabaa Muthuirulandi Sethuve, Shalini Anandan, Dhivya Murugan , Kalaiarasi Asokan ,Karthick Vasudevan, Jobin John Jaco , Kamini Walia, Joy Sarojini Michael, Balaji  Veeraraghavan. Hybrid genome assembly of Shigella sonnei reveals the novel finding of chromosomal 2 integration of an IncFII plasmid carrying mphA gene. Access Microbiology.
• Vasudevan K, Ragupathi NK, Jacob JJ, Veeraraghavan B. Highly accurate-single chromosomal complete genomes using IonTorrent and MinION sequencing of clinical pathogens. Genomics. 2020 Jan 1;112(1):545-51.
• Vijayakumar S, Wattal C, JK O, Bhattacharya S, Vasudevan K, Anandan S, Walia K, Veeraraghavan B. Insights into the complete genomes of carbapenem-resistant Acinetobacter baumannii harbouring bla OXA-23, bla OXA-420 and bla NDM-1 genes using a hybrid-assembly approach. Access Microbiology. 2020 Jun 5:acmi000140.
• Ragupathi NK, Vasudevan K, Venkatesan M, Veeraraghavan B. First Indian report on B4/H24RxC ST410 type MDR Escherichia coli from bloodstream infection with blaOXA-181 and blaCTX-M-15. Journal of Global Antimicrobial Resistance. 2020 Jun 27.
• Ragupathi NK, Sethuvel DP, Anandan S, Murugan D, Asokan K, Neethi Mohan RG, Vasudevan K, Veeraraghavan B. First hybrid complete genome of Aeromonas veronii reveals chromosomemediated novel structural variant mcr-3.30 from a human clinical sample. Access Microbiology. 2020 Apr;2(4):e000103.
• Bakthavatchalam YD, Vasudevan K, Neeravi A, Perumal R, Veeraraghavan B. First draft genome sequence of linezolid and rifampicin resistant Staphylococcus haemolyticus. Japanese Journal of Infectious Diseases. 2020:JJID-2019.
• Devanga Ragupathi NK, Veeraraghavan B, Muthuirulandi Sethuvel DP, Anandan S, Vasudevan K, Neeravi AR, Daniel JL, Sathyendra S, Iyadurai R, Mutreja A. First Indian report on genome-wide comparison of multidrug-resistant Escherichia coli from blood stream infections. Plos one. 2020 Feb 26;15(2):e0220428.
• Sethuvel DP, Ragupathi NK, Bakthavatchalam YD, Vijayakumar S, Varghese R, Shankar C, Jacob JJ, Vasudevan K, Elangovan D, Balaji V. Current strategy for local-to global-level molecular epidemiological characterisation of global antimicrobial resistance surveillance system pathogens. Indian journal of medical microbiology. 2019 Apr 1;37(2):147.
• Sethuvel DP, Veeraraghavan B, Vasudevan K, Ragupathi NK, Murugan D, Walia K, Anandan S. Complete genome analysis of clinical Shigella strains reveals plasmid pSS1653 with resistance determinants: a triumph of hybrid approach. Gut pathogens. 2019 Dec 1;11(1):55.
• Amladi A, Ragupathi ND, Vasudevan K, Venkatesan M, Anandan S, Veeraraghavan B. First report of Burkholderia pseudomallei ST412 and ST734 clones harbouring blaOXA-57 but susceptible to imipenem in India. New microbes and new infections. 2019 Nov 1;32:100613.Jacob JJ, Anandan S, Venkatesan M, Neeravi A, Vasudevan K, Pragasam AK, Veeraraghavan B. Genomic analysis of human invasive Salmonella enterica serovar Typhimurium ST313 isolate B3589 from India. Infection, Genetics and Evolution. 2019 Sep 1;73:416-24.
• Jacob JJ, Veeraraghavan B, Vasudevan K. Metagenomic next-generation sequencing in clinical microbiology. Indian journal of medical microbiology. 2019 Apr 1;37(2):133.
• Jacob JJ, Vasudevan K Veeraraghavan B, Karthik Gunasekaran. Genomic evolution of SARS CoV2 in India and Vaccine impact. Indian journal of medical microbiology. (Accepted)
• Sharma NC, Anandan S, Ragupathi NK, Sethuvel DP, Vasudevan K, Kumar D, Gupta SK, Sangal L, Murugesan V, Veeraraghavan B. Genetic diversity of clinical Bordetella pertussis ST2 strains in comparison with vaccine reference strains of India. bioRxiv. 2019 Jan 1:573543.
• Nagasundaram. N, Hailong Zhu, Jiming Liu, Karthick. V, George Priya Doss. C, Chiranjib Chakraborty, Luonan Chen (2015) Analysing the effect of mutation on protein function and discovering potential inhibitors of CDK4: Molecular modelling and dynamics studies. PLOS ONE (impact factor: 3.2) (Scopus Indexed)
• Nagasundaram N, George Priya Doss C, Chiranjib Chakraborty, Karthick V, Thirumal Kumar D, Balaji V, Siva R, Aiping Lu, Zhang Ge, Hailong Zhu. Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach. Sci Rep. 2016; 6: 30106
• Karthick. V, Nagasundaram. N,George Priya Doss. C, Chiranjib Chakraborty, Xiaonong Zhou, Jiming Liu, Hailong Zhu (2015). Receptor-based virtual screening approach for the discovery of potential inhibitors of Ebola virus VP40. Infectious Diseases of Poverty.
• Karthick V, Ramanathan (2013) Insight into the Oseltamivir Resistance R292K Mutation in H5N1 Influenza Virus - A Molecular Docking and Molecular Dynamics Approach. Cell Biochem Biophys.
• Karthick V, Ramanathan K (2013) Virtual screening for oseltamivir-resistant a (H5N1) influenza neuraminidase from traditional Chinese medicine database: a combined molecular docking with molecular dynamics approach. Springerplus. 2, 115.
• Karthick V, Ramanathan (2013) Computational investigation of oseltamivir resistance H274Y mutation in influenza A (H5N1) virus. Medicinal chemistry research.
• Karthick V, Ramanathan K (2013) Investigation of Peramivir-Resistant R292K Mutation in A (H1N9) Influenza Virus by Molecular Dynamics Simulation Approach. Journal of Bioinformatics and Intelligent Control 2, 1-5.
• Karthick V, Shanthi V, Rajasekaran R, Ramanathan K (2013). In silico analysis of drugresistant mutant of neuraminidase (N294S) against oseltamivir. Protoplasma. 2013 250(1):197207.
• Karthick V, Shanthi V, Rajasekaran R, Ramanathan K. (2012) Exploring the Cause of Oseltamivir Resistance Against Mutant H274Y Neuraminidase by Molecular Simulation Approach. ApplBiochem Biotechnol. 2012, 167, 237–249.
• Karthick V, Ramanathan K, Shanthi V, Rajasekaran R. (2013) Identification of Potential Inhibitors of H5N1 Influenza A VirusNeuraminidase by Ligand-Based Virtual Screening Approach. Cell Biochem Biophys. 2013 DOI 10.1007/s12013-012-9510-7.
• Ramanathan K , Shanthi V, Pratik U, Karthick V, Dhanasekaran D. (2013). Computational analysis of amprenavir resistance triple mutant (V32I, I47V and V82I) in HIV-1 protease. Network Modeling Analysis in Health Informatics and Bioinformatics, 3 (1), 1-8
• Choudhary P, Singh J, Karthick V, Shanthi V, Rajasekaran R, Ramanathan K. (2013) In silico prediction of functional loss of cst3 gene in hereditary cerebral amyloid angiopathy. Bangladesh J. Pharmacol. 8 (4), 390-394.
• Lohitesh K, Karthick V, Dhanasekaran D, RaoSethumadhavan, Shanthi V, Ramanathan K (2013).
• Prediction of Functional Loss of Human TWIK-Related Spinal Cord K+ Gene Associated with a. Migraine Disease Using Nanoseconds Simulation Study. J. Bionanosci. 7, 654659.
• Karthick V, Ramanathan K (2014). Computational investigation of drug resistant mutant of M2 proton channel (S31N) against rimantadine. Cell Biochemistry and Biophysics
• Karthick V, Ramanathan K, Andrey A. Toropov, Alla P. Toropova. (2014). Discovery of potential, non-toxic influenza virus inhibitor by computational techniques. Molecular Informatics.
• Kanika Verma, Kaavya Kannan, V. Shanthi, Rao Sethumadhavan, V. Karthick and K.  Ramanathan (2016) Exploring β-tubulin inhibitors from plant origin using computational approach, Phytochemical Analysis.

Research Summary

Dr. Karthick Vasudevan is experienced bioinformatician who is passionate about in finding out new clues for treating the infectious diseases and cancer using advanced genomic and proteomics approaches. As a part of genomic research, Dr. Karthick Vasudevan have published in the major international peer-reviewed journals like nature communication, genomics and microbial genomics.

International Visits

Hong Kong Baptist University-2014-2015 &2016-2018