Dr. Vivek Keshri Assistant Professor

Specialization

Bioinformatics data analysis- antibiotic resistance genes identification, differential expression profiling, next-generation sequencing data analysis

Qualification

Ph.D.

Teaching Experience

7 Years

Publications In Refereed Journals

• Human metallo-β-lactamase enzymes degrade penicillin

  Diene SM, Pinault L, Keshri V, Armstrong N, Khelaifia S, Chabrière E, Caetano-Anolles G, Colson P, La Scola B, Rolain JM, Pontarotti P, Raoult D. Sci Rep. 2019 Aug 21;9(1):12173. doi: 10.1038/s41598-019-48723-y. PMID: 31434986; PMCID: PMC6704141.

• Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases

  Keshri V, Chabrière E, Pinault L, Colson P, Diene SM, Rolain JM, Raoult D, Pontarotti P. Int J Mol Sci. 2020 Aug 29;21(17):6260. doi: 10.3390/ijms21176260. PMID: 32872436; PMCID: PMC7504333.

• Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea

  Diene SM, Pinault L, Armstrong N, Azza S, Keshri V, Khelaifia S, Chabrière E, Caetano-Anolles G, Rolain JM, Pontarotti P, Raoult D. Life (Basel). 2020 Nov 14;10(11):280. doi: 10.3390/life10110280. PMID: 33202677; PMCID: PMC7697635.

• Phylogenomic Analysis of β-Lactamase in Archaea and Bacteria Enables the Identification of Putative New Members.

  Keshri V, Panda A, Levasseur A, Rolain JM, Pontarotti P, Raoult D. Genome Biol Evol. 2018 Apr 1;10(4):1106-1114. doi: 10.1093/gbe/evy028. PMID: 29672703; PMCID: PMC5905574.

• The functional convergence of antibiotic resistance in β-lactamases is not conferred by a simple convergent substitution of amino acid.

  Keshri V, Arbuckle K, Chabrol O, Rolain JM, Raoult D, Pontarotti P. Evol Appl. 2019 Jul 18;12(9):1812-1822. doi: 10.1111/eva.12835. PMID: 31548859; PMCID: PMC6752183.

• An Integrative Database of β-Lactamase Enzymes: Sequences, Structures, Functions, and Phylogenetic Trees.

• Keshri V, Diene SM, Estienne A, Dardaillon J, Chabrol O, Tichit L, Rolain JM, Raoult D, Pontarotti P. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02319-18. doi: 10.1128/AAC.02319-18. Print 2019 May. PMID: 30783007

Other Publications

• Structure Prediction and Binding Site Analysis of Hepatotoxic Microcystin-LR Degrading MlrC-Like Protein

  from Burkholderia sp. using Computational Approaches

  Singh DP, Prabha R, Keshri V, and Abhilash PC

  2016, Current Research in Bioinformatics

• Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv

  oryzae PXO99A pathogenic to rice

  Keshri V, Singh DP, Prabha R, Rai A, and Sharma AK. 2013, 3Biotech (Springer) [PMID: 28324466]